R-loopReORA

R-loopReORA is an online tool to determine whether a user-provided gene list is significantly enriched for curated R-loop regulators by hypergeometric over-representation testing, and to visualize shared versus unique genes with a Venn diagram. Regulators are categorized by their roles in promoting or suppressing R-loop formation, enabling directional interpretation of R-loop regulatory alterations.

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1. Please provide the content of the file to be analyzed:

Please enter tab-delimited data with a header. The first column should contain gene identifiers (Ensembl ID recommended; Entrez ID or gene symbol also accepted). For over-representation analysis, provide the gene list of interest (for example, differentially expressed genes). Additional columns are allowed and ignored.

2. Or you can upload a tab-delimited text file.

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Download example file

Upload a tab-delimited file or paste text directly, then submit the analysis.

Result Display

After submission, you can preview the Venn diagram, hypergeometric p-value summary, and overlapping gene table. Clicking an Entrez ID in the overlap table opens the corresponding regulator page.