R-loop-forming regions provide genome-wide human R-loop maps derived from the integration of multiple R-loop mapping technologies. Two types of downloadable files are available: quantitative R-loops (V2 only) and confidence-level R-loop zones (available in both V1 and V2). Quantitative R-loops contain normalized and integrated R-loop scores that reflect the relative support and signal strength across multiple technologies. Confidence-level R-loop zones classify R-loop regions according to the minimum number of independent technologies supporting each region; higher confidence levels indicate more conservative and higher-confidence R-loop-forming regions.

A protein is considered an R-loop regulator if it binds to, stabilizes, resolves, or degrades RNA hybrids, or if the levels of R-loops or RNA hybrids are altered upon chemical or genetic manipulation of the protein. The downloadable files provide gene lists, GTEx and TCGA tissue expression profiles, and the potential targeted quantitative R-loops and confidence-level R-loop zones of curated R-loop regulators.