Description

This section integrates diverse epigenomic datasets, including ATAC-seq (chromatin accessibility), whole-genome bisulfite sequencing (WGBS), and a comprehensive collection of histone modification ChIP-seq data covering marks such as H3K4me1, H3K4me3, H3K36me3 and others. ATAC-seq reports chromatin openness; methylation in different contexts reflects genome-wide epigenetic regulation; histone modifications annotate various functional states like promoters, enhancers, and active transcription. R-loop formation is intimately linked to the chromatin landscape—they preferentially occur in open, actively transcribed regions, often colocalize with active promoter marks (e.g., H3K4me3), and may be influenced by local DNA methylation status. Together, these epigenomic tracks provide multi-layered chromatin features for exploring the regulatory context and biological significance of R-loops. Genomic coordinates were lifted to mm39 assembly using LiftOver.