Description

This track integrates XR-seq datasets to map genomic regions undergoing nucleotide excision repair (NER). XR-seq captures and sequences oligonucleotides excised during NER, providing a genome-wide and high-resolution readout of DNA repair activity. These tracks provide complementary information for investigating the relationship between DNA repair activity and R-loop formation.

Reference

van der Weegen Y, Golan-Berman H, Mevissen TET, et al, The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.. Nat Commun. 2020 Apr 30;11(1):2104. PMID: 32355176

Golan Berman H, Chauhan P, Shalev S, et al, Genomic Characterization of Cisplatin Response Uncovers Priming of Cisplatin-Induced Genes in a Resistant Cell Line.. Int J Mol Sci. 2021 May 28;22(11). PMID: 34071702

Wu Y, Adeel MM, Sancar A,, et al, Nucleotide Excision Repair of Aflatoxin-induced DNA Damage within the 3D Human Genome Organization.. bioRxiv. 2023 Sep 29. PMID: 37808841