DNA replication Track Settings
 
DNA replication   (All R-loopBase Data tracks)

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Select subtracks by cell line and technology: (help)
 All Cell Line HCT116  HeLa-S3  IMR-90  K562  MCF-7 
Technology
Repli-seq 
LD-OK-seq 
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  Cell Line↓1 Technology↓2   Track Name↓3  
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 HCT116  LD-OK-seq  bigwig_HCT116_LD-OK-seq_minus   Schema 
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 HCT116  LD-OK-seq  bigwig_HCT116_LD-OK-seq_plus   Schema 
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 HeLa-S3  Repli-seq  bigwig_Hela-S3_Repli-seq_G1bphase   Schema 
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 HeLa-S3  Repli-seq  bigwig_HeLa-S3_Repli-seq_G2phase   Schema 
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 HeLa-S3  Repli-seq  bigwig_HeLa-S3_Repli-seq_S1phase   Schema 
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 HeLa-S3  Repli-seq  bigwig_HeLa-S3_Repli-seq_S2phase   Schema 
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 HeLa-S3  Repli-seq  bigwig_HeLa-S3_Repli-seq_S3phase   Schema 
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 HeLa-S3  Repli-seq  bigwig_HeLa-S3_Repli-seq_S4phase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_G1bphase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_G2phase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_S1phase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_S2phase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_S3phase   Schema 
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 IMR-90  Repli-seq  bigwig_IMR-90_Repli-seq_S4phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_G1phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_G2phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_S1phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_S2phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_S3phase   Schema 
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 K562  Repli-seq  bigwig_K562_Repli-seq_S4phase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_G1bphase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_G2phase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_S1phase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_S2phase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_S3phase   Schema 
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 MCF-7  Repli-seq  bigwig_MCF-7_Repli-seq_S4phase   Schema 
    

Description

This track integrates genome-wide datasets related to DNA replication, including Repli-seq and OK-seq. Repli-seq measures replication timing across the genome by profiling newly synthesized DNA from cells isolated at different stages of S phase, whereas OK-seq maps replication fork directionality based on the distribution of Okazaki fragments. Together, these datasets provide complementary information on replication timing, fork progression, and the organization of DNA replication across the genome.

Reference

Zhu X, Bektash A, Hatoyama Y, et al, Regulated TRESLIN-MTBP loading governs initiation zones and replication timing in human DNA replication.. Nat Commun. 2025 Dec 2;16(1):10069. PMID: 41331242