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Comments and Description Text from UniProtKB
ID:RHG32_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 32; AltName: Full=Brain-specific Rho GTPase-activating protein; AltName: Full=GAB-associated Cdc42/Rac GTPase-activating protein; AltName: Full=GC-GAP; AltName: Full=GTPase regulator interacting with TrkA; AltName: Full=Rho-type GTPase-activating protein 32; AltName: Full=Rho/Cdc42/Rac GTPase-activating protein RICS; AltName: Full=RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; AltName: Full=p200RhoGAP; AltName: Full=p250GAP; FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). SUBUNIT: Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity). INTERACTION: P06241:FYN; NbExp=4; IntAct=EBI-308663, EBI-515315; SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine (By similarity). Cytoplasm, cell cortex. Endosome membrane (By similarity). Golgi apparatus membrane (By similarity). Endoplasmic reticulum membrane (By similarity). Membrane. Note=Association to membrane via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment. Colocalizes with GAB2 at the cell membrane. TISSUE SPECIFICITY: Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen. DOMAIN: The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity). PTM: Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity). SIMILARITY: Belongs to the PX domain-containing GAP family. SIMILARITY: Contains 1 PX (phox homology) domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAA34432.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Protein Domain and Structure Information
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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