Human Gene ARHGEF28 (ENST00000545377.5) Description and Page Index
  Description: Homo sapiens Rho guanine nucleotide exchange factor 28 (ARHGEF28), transcript variant 1, mRNA. (from RefSeq NM_001080479)
Gencode Transcript: ENST00000545377.5
Gencode Gene: ENSG00000214944.9
Transcript (Including UTRs)
   Position: hg38 chr5:73,626,158-73,941,992 Size: 315,835 Total Exon Count: 37 Strand: +
Coding Region
   Position: hg38 chr5:73,684,852-73,941,013 Size: 256,162 Coding Exon Count: 36 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: ARG28_HUMAN
DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 28; AltName: Full=190 kDa guanine nucleotide exchange factor; Short=p190-RhoGEF; Short=p190RhoGEF; AltName: Full=Rho guanine nucleotide exchange factor;
FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).
SUBUNIT: Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the microtubule radial and cortical systems (By similarity).
PTM: Phosphorylated on tyrosine upon stimulation of cells by laminin (By similarity).
SIMILARITY: Contains 1 DH (DBL-homology) domain.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger.
SEQUENCE CAUTION: Sequence=AAH12946.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC02707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

+  Protein Domain and Structure Information
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+  Other Names for This Gene
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+  Methods, Credits, and Use Restrictions
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