Human Gene BAG5 (ENST00000337322.4) Description and Page Index
  Description: Homo sapiens BAG cochaperone 5 (BAG5), transcript variant 1, mRNA. (from RefSeq NM_001015049)
Gencode Transcript: ENST00000337322.4
Gencode Gene: ENSG00000166170.10
Transcript (Including UTRs)
   Position: hg38 chr14:103,559,619-103,562,298 Size: 2,680 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr14:103,559,821-103,562,007 Size: 2,187 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:103,559,619-103,562,298)mRNA (may differ from genome)Protein (488 aa)
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-  Comments and Description Text from UniProtKB
  ID: BAG5_HUMAN
DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 5; Short=BAG-5; AltName: Full=Bcl-2-associated athanogene 5;
FUNCTION: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity).
DOMAIN: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
SIMILARITY: Contains 5 BAG domains.
SEQUENCE CAUTION: Sequence=BAA74896.1; Type=Erroneous initiation;

+  Protein Domain and Structure Information
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+  Other Names for This Gene
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+  Methods, Credits, and Use Restrictions
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