Human Gene CPD (ENST00000225719.9) Description and Page Index
  Description: Homo sapiens carboxypeptidase D (CPD), transcript variant 1, mRNA. (from RefSeq NM_001304)
Gencode Transcript: ENST00000225719.9
Gencode Gene: ENSG00000108582.12
Transcript (Including UTRs)
   Position: hg38 chr17:30,378,927-30,469,989 Size: 91,063 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg38 chr17:30,378,981-30,464,814 Size: 85,834 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:30,378,927-30,469,989)mRNA (may differ from genome)Protein (1380 aa)
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-  Comments and Description Text from UniProtKB
  ID: CBPD_HUMAN
DESCRIPTION: RecName: Full=Carboxypeptidase D; EC=3.4.17.22; AltName: Full=Metallocarboxypeptidase D; AltName: Full=gp180; Flags: Precursor;
CATALYTIC ACTIVITY: Releases C-terminal Arg and Lys from polypeptides.
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.0-6.5;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
DOMAIN: There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity.
SIMILARITY: Belongs to the peptidase M14 family.

+  Protein Domain and Structure Information
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+  Other Names for This Gene
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+  Methods, Credits, and Use Restrictions
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