Human Gene MAP1A (ENST00000300231.6) Description and Page Index

Description: Homo sapiens microtubule associated protein 1A (MAP1A), mRNA. (from RefSeq NM_002373)
Gencode Transcript: ENST00000300231.6
Gencode Gene: ENSG00000166963.13
Transcript (Including UTRs)
Position: hg38 chr15:43,517,608-43,531,611 Size: 14,004 Total Exon Count: 6 Strand: +
Coding Region
Position: hg38 chr15:43,521,474-43,530,224 Size: 8,751 Coding Exon Count: 3

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: MAP1A_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 1A; Short=MAP-1A; AltName: Full=Proliferation-related protein p80; Contains: RecName: Full=MAP1A heavy chain; Contains: RecName: Full=MAP1 light chain LC2; FUNCTION: Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements. SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity). INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-929047, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). TISSUE SPECIFICITY: Brain. DOMAIN: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules. PTM: Phosphorylated by CSNK1D (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: LC2 is generated from MAP1A by proteolytic processing. SIMILARITY: Belongs to the MAP1 family.