ID:HS105_HUMAN DESCRIPTION: RecName: Full=Heat shock protein 105 kDa; AltName: Full=Antigen NY-CO-25; AltName: Full=Heat shock 110 kDa protein; FUNCTION: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). SUBUNIT: Interacts with HSPA8/HSC70 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity (By similarity). SIMILARITY: Belongs to the heat shock protein 70 family. SEQUENCE CAUTION: Sequence=AAC18044.1; Type=Erroneous initiation; Sequence=BAA13192.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HSPH1ID40891ch13q12.html";
ModBase Predicted Comparative 3D Structure on Q92598
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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