ID:LAS1L_HUMAN DESCRIPTION: RecName: Full=Ribosomal biogenesis protein LAS1L; AltName: Full=Protein LAS1 homolog; FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. SUBUNIT: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. INTERACTION: Q96T60:PNKP; NbExp=1; IntAct=EBI-1051591, EBI-1045072; SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. SIMILARITY: Belongs to the LAS1 family. SEQUENCE CAUTION: Sequence=BAB84913.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q9Y4W2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Other Names for This Gene
Press "+" in the title bar above to open this section.
Methods, Credits, and Use Restrictions
Press "+" in the title bar above to open this section.
