Human Gene TLE3 (ENST00000558379.5) Description and Page Index

Description: Homo sapiens TLE family member 3, transcriptional corepressor (TLE3), transcript variant 4, mRNA. (from RefSeq NM_001282980)
Gencode Transcript: ENST00000558379.5
Gencode Gene: ENSG00000140332.17
Transcript (Including UTRs)
Position: hg38 chr15:70,050,097-70,096,798 Size: 46,702 Total Exon Count: 20 Strand: -
Coding Region
Position: hg38 chr15:70,050,097-70,096,798 Size: 46,702 Coding Exon Count: 20

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: TLE3_HUMAN DESCRIPTION: RecName: Full=Transducin-like enhancer protein 3; AltName: Full=Enhancer of split groucho-like protein 3; Short=ESG3; FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). SUBUNIT: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Placenta and lung. PTM: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. SIMILARITY: Belongs to the WD repeat Groucho/TLE family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAB13373.1; Type=Erroneous initiation;