Human Gene THOC2 (ENST00000355725.8) Description and Page Index
Description: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex.The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. (from UniProt Q8NI27) Gencode Transcript: ENST00000355725.8 Gencode Gene: ENSG00000125676.20 Transcript (Including UTRs) Position: hg38 chrX:123,610,198-123,733,056 Size: 122,859 Total Exon Count: 39 Strand: - Coding Region Position: hg38 chrX:123,610,936-123,733,022 Size: 122,087 Coding Exon Count: 38
