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Comments and Description Text from UniProtKB
ID:SEC20_HUMAN DESCRIPTION: RecName: Full=Vesicle transport protein SEC20; AltName: Full=BCL2/adenovirus E1B 19 kDa protein-interacting protein 1; AltName: Full=Transformation-related gene 8 protein; Short=TRG-8; FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy. SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein. SUBCELLULAR LOCATION: Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. TISSUE SPECIFICITY: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine. PTM: 'Lys-63'-linked polyubiquitination by RNF185 allows recruiting of autophagy receptor SQSTM1, which simultaneously binds both ubiquitin and LC3 to link ubiquitination and autophagy. MISCELLANEOUS: Silencing of BNIP1 disrupts ER morphology. SIMILARITY: Belongs to the SEC20 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bnip1/";
ModBase Predicted Comparative 3D Structure on Q12981
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