ID:1433Z_HUMAN DESCRIPTION: RecName: Full=14-3-3 protein zeta/delta; AltName: Full=Protein kinase C inhibitor protein 1; Short=KCIP-1; FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. SUBUNIT: Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr- phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. INTERACTION: Q29495:AANAT (xeno); NbExp=3; IntAct=EBI-347088, EBI-446413; P00519:ABL1; NbExp=2; IntAct=EBI-347088, EBI-375543; Q9P0K1-3:ADAM22; NbExp=3; IntAct=EBI-347088, EBI-1567267; O00257-3:CBX4; NbExp=2; IntAct=EBI-347088, EBI-4392727; P23528:CFL1; NbExp=2; IntAct=EBI-347088, EBI-352733; P00533:EGFR; NbExp=4; IntAct=EBI-347088, EBI-297353; P30793:GCH1; NbExp=4; IntAct=EBI-347088, EBI-958183; Q99683:MAP3K5; NbExp=2; IntAct=EBI-347088, EBI-476263; Q7KZI7:MARK2; NbExp=3; IntAct=EBI-347088, EBI-516560; P27448:MARK3; NbExp=6; IntAct=EBI-347088, EBI-707595; Q9NYL2:MLTK; NbExp=4; IntAct=EBI-347088, EBI-602273; Q8TEW0:PARD3; NbExp=3; IntAct=EBI-347088, EBI-81968; P04049:RAF1; NbExp=3; IntAct=EBI-347088, EBI-365996; P57059:SIK1; NbExp=4; IntAct=EBI-347088, EBI-1181640; Q9Y2K2:SIK3; NbExp=5; IntAct=EBI-347088, EBI-1181460; O00506:STK25; NbExp=2; IntAct=EBI-347088, EBI-618295; P36897:TGFBR1; NbExp=4; IntAct=EBI-347088, EBI-1027557; P84198:VIM (xeno); NbExp=5; IntAct=EBI-347088, EBI-457639; SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes. PTM: The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1. SIMILARITY: Belongs to the 14-3-3 family. CAUTION: Was originally (PubMed:1577711) thought to have phospholipase A2 activity. SEQUENCE CAUTION: Sequence=AAH51814.1; Type=Erroneous initiation; Sequence=AAH73141.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on P63104
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