ID:EVI1_HUMAN DESCRIPTION: RecName: Full=MDS1 and EVI1 complex locus protein EVI1; AltName: Full=Ecotropic virus integration site 1 protein homolog; Short=EVI-1; FUNCTION: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. SUBUNIT: Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling. INTERACTION: P56546:Ctbp2 (xeno); NbExp=3; IntAct=EBI-1384862, EBI-1384883; Q96EB6:SIRT1; NbExp=2; IntAct=EBI-1384862, EBI-1802965; Q9UBK9:UXT; NbExp=5; IntAct=EBI-1384862, EBI-357355; SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. DOMAIN: Both zinc finger regions are required for the transcriptional activation of PBX1. PTM: Phosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: May be acetylated by CREBBP and KAT2B. DISEASE: Note=A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1. SIMILARITY: Contains 10 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=AAB29907.1; Type=Erroneous initiation; Sequence=AAB37456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI30521.1; Type=Erroneous initiation; Sequence=BAH14103.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EVI103q26ID19.html";
ModBase Predicted Comparative 3D Structure on Q03112
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