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Comments and Description Text from UniProtKB
ID:FKB15_HUMAN DESCRIPTION: RecName: Full=FK506-binding protein 15; Short=FKBP-15; AltName: Full=133 kDa FK506-binding protein; Short=133 kDa FKBP; Short=FKBP-133; AltName: Full=WASP and FKBP-like; Short=WAFL; FUNCTION: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement. SUBUNIT: Interacts with WIP and actin. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome. Note=Present in axons and neuronal growth cones (By similarity). DOMAIN: The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity). DOMAIN: The central coiled-coil region is responsible for association with early endosomes. SIMILARITY: Belongs to the FKBP-type PPIase family. SIMILARITY: Contains 1 PPIase FKBP-type domain. SEQUENCE CAUTION: Sequence=AAH09609.1; Type=Erroneous initiation; Sequence=BAA31649.1; Type=Erroneous initiation; Sequence=CAI10963.1; Type=Erroneous initiation; Sequence=CAI10964.1; Type=Erroneous initiation;
Protein Domain and Structure Information
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