Human Gene NFATC4 (ENST00000556279.5) Description and Page Index

Description: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. (from UniProt Q14934)
Gencode Transcript: ENST00000556279.5
Gencode Gene: ENSG00000100968.14
Transcript (Including UTRs)
Position: hg38 chr14:24,367,468-24,377,705 Size: 10,238 Total Exon Count: 11 Strand: +
Coding Region
Position: hg38 chr14:24,367,587-24,377,705 Size: 10,119 Coding Exon Count: 11

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR002909 - IPT_TIG_rcpt
IPR008366 - NFAT
IPR008967 - p53-like_TF_DNA-bd
IPR011539 - RHD

Pfam Domains:
PF00554 - Rel homology DNA-binding domain
PF01833 - IPT/TIG domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2YRP - NMR

ModBase Predicted Comparative 3D Structure on Q14934


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