Human Gene LGALS3BP (ENST00000262776.8) Description and Page Index
  Description: Homo sapiens galectin 3 binding protein (LGALS3BP), mRNA. (from RefSeq NM_005567)
Gencode Transcript: ENST00000262776.8
Gencode Gene: ENSG00000108679.13
Transcript (Including UTRs)
   Position: hg38 chr17:78,971,255-78,979,923 Size: 8,669 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg38 chr17:78,971,576-78,977,191 Size: 5,616 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

+  Sequence and Links to Tools and Databases
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-  Comments and Description Text from UniProtKB
  ID: LG3BP_HUMAN
DESCRIPTION: RecName: Full=Galectin-3-binding protein; AltName: Full=Basement membrane autoantigen p105; AltName: Full=Lectin galactoside-binding soluble 3-binding protein; AltName: Full=Mac-2-binding protein; Short=MAC2BP; Short=Mac-2 BP; AltName: Full=Tumor-associated antigen 90K; Flags: Precursor;
FUNCTION: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
SUBUNIT: Homodimers and homomultimers. The multimers form ring- like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID.
SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 1 SRCR domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011705 - BACK
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR001190 - Srcr_rcpt
IPR017448 - Srcr_rcpt-rel

Pfam Domains:
PF07707 - BTB And C-terminal Kelch
PF00530 - Scavenger receptor cysteine-rich domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1BY2 - X-ray


ModBase Predicted Comparative 3D Structure on Q08380
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-  Other Names for This Gene
  UCSC ID: ENST00000262776.8
Representative RNA: NM_005567
Protein: Q08380 (aka LG3BP_HUMAN or L3BP_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.