Human Gene CTNNBL1 (ENST00000373469.1) Description and Page Index
Description: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. (from UniProt Q8WYA6) Gencode Transcript: ENST00000373469.1 Gencode Gene: ENSG00000132792.19 Transcript (Including UTRs) Position: hg38 chr20:37,777,273-37,872,129 Size: 94,857 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr20:37,777,351-37,872,013 Size: 94,663 Coding Exon Count: 9
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Comments and Description Text from UniProtKB
ID:CTBL1_HUMAN DESCRIPTION: RecName: Full=Beta-catenin-like protein 1; AltName: Full=Nuclear-associated protein; Short=NAP; AltName: Full=Testis development protein NYD-SP19; FUNCTION: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. SUBUNIT: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid. SEQUENCE CAUTION: Sequence=AAQ15267.1; Type=Frameshift; Positions=96; Sequence=BAB14992.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q8WYA6
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