ID:PDE1A_HUMAN DESCRIPTION: RecName: Full=Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Short=Cam-PDE 1A; EC=3.1.4.17; AltName: Full=61 kDa Cam-PDE; AltName: Full=hCam-1; FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). SUBUNIT: Homodimer (By similarity). TISSUE SPECIFICITY: Several tissues, including brain, kidney, testes and heart. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
ModBase Predicted Comparative 3D Structure on P54750
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