Human Gene CTLA4 (ENST00000487393.1) Description and Page Index

Description: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (from UniProt P16410)
Gencode Transcript: ENST00000487393.1
Gencode Gene: ENSG00000163599.17
Transcript (Including UTRs)
Position: hg38 chr2:203,867,943-203,872,812 Size: 4,870 Total Exon Count: 2 Strand: +
Coding Region
Position: hg38 chr2:203,867,943-203,872,775 Size: 4,833 Coding Exon Count: 2

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008096 - CTLA4
IPR013783 - Ig-like_fold
IPR013106 - Ig_V-set
IPR003596 - Ig_V-set_subgr

Pfam Domains:
PF07686 - Immunoglobulin V-set domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1AH1 - NMR	1H6E - X-ray	1I85 - X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
1I8L - X-ray	2X44 - X-ray	3BX7 - X-ray
3OSK - X-ray

ModBase Predicted Comparative 3D Structure on P16410


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.