Human Gene PAX6 (ENST00000379107.7) Description and Page Index
Description: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes. (from UniProt P26367) Gencode Transcript: ENST00000379107.7 Gencode Gene: ENSG00000007372.24 Transcript (Including UTRs) Position: hg38 chr11:31,789,194-31,810,305 Size: 21,112 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr11:31,789,934-31,806,411 Size: 16,478 Coding Exon Count: 11
ModBase Predicted Comparative 3D Structure on P26367
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