Human Gene H3-3A (ENST00000366813.1) Description and Page Index
Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (from UniProt P84243) Gencode Transcript: ENST00000366813.1 Gencode Gene: ENSG00000163041.13 Transcript (Including UTRs) Position: hg38 chr1:226,063,977-226,072,001 Size: 8,025 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr1:226,064,352-226,071,479 Size: 7,128 Coding Exon Count: 3
ModBase Predicted Comparative 3D Structure on P84243
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