ID:PRAF2_HUMAN DESCRIPTION: RecName: Full=PRA1 family protein 2; FUNCTION: May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis. SUBUNIT: Interacts with CCR5 and GDE1. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. SIMILARITY: Belongs to the PRA1 family.
Protein Domain and Structure Information
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
