ID:RAE2_HUMAN DESCRIPTION: RecName: Full=Rab proteins geranylgeranyltransferase component A 2; AltName: Full=Choroideraemia-like protein; AltName: Full=Rab escort protein 2; Short=REP-2; FUNCTION: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. SUBUNIT: Monomer. Interacts with Rab and Rab GGTase. MISCELLANEOUS: Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP- 1. SIMILARITY: Belongs to the Rab GDI family.
Pfam Domains: PF00996 - GDP dissociation inhibitor
ModBase Predicted Comparative 3D Structure on P26374
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