ID:IL33_HUMAN DESCRIPTION: RecName: Full=Interleukin-33; Short=IL-33; AltName: Full=Interleukin-1 family member 11; Short=IL-1F11; AltName: Full=Nuclear factor from high endothelial venules; Short=NF-HEV; Flags: Precursor; FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. INTERACTION: Q01638:IL1RL1; NbExp=2; IntAct=EBI-724057, EBI-993762; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. PTM: Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. SIMILARITY: Belongs to the IL-1 family. Highly divergent. CAUTION: Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.
ModBase Predicted Comparative 3D Structure on O95760
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