Human Gene CD14 (ENST00000302014.11) Description and Page Index

Description: Homo sapiens CD14 molecule (CD14), transcript variant 1, mRNA. (from RefSeq NM_000591)
Gencode Transcript: ENST00000302014.11
Gencode Gene: ENSG00000170458.14
Transcript (Including UTRs)
Position: hg38 chr5:140,631,732-140,633,175 Size: 1,444 Total Exon Count: 2 Strand: -
Coding Region
Position: hg38 chr5:140,631,856-140,633,071 Size: 1,216 Coding Exon Count: 2

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: CD14_HUMAN DESCRIPTION: RecName: Full=Monocyte differentiation antigen CD14; AltName: Full=Myeloid cell-specific leucine-rich glycoprotein; AltName: CD_antigen=CD14; Contains: RecName: Full=Monocyte differentiation antigen CD14, urinary form; Contains: RecName: Full=Monocyte differentiation antigen CD14, membrane-bound form; Flags: Precursor; FUNCTION: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. PTM: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. SIMILARITY: Contains 11 LRR (leucine-rich) repeats. WEB RESOURCE: Name=Wikipedia; Note=CD14 entry; URL="http://en.wikipedia.org/wiki/CD14";