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Comments and Description Text from UniProtKB
ID:TKN4_HUMAN DESCRIPTION: RecName: Full=Tachykinin-4; AltName: Full=Preprotachykinin-C; Short=PPT-C; Contains: RecName: Full=Endokinin-A; Short=EKA; Contains: RecName: Full=Endokinin-A/B; Short=EKA/B; Contains: RecName: Full=Endokinin-C; Short=EKC; Flags: Precursor; FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. SUBCELLULAR LOCATION: Secreted (Probable). TISSUE SPECIFICITY: Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. SIMILARITY: Belongs to the tachykinin family. SEQUENCE CAUTION: Sequence=AAI00841.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00843.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAI00844.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAN77128.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=EAW94657.1; Type=Erroneous gene model prediction;
ModBase Predicted Comparative 3D Structure on Q86UU9
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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