Human Gene MANF (ENST00000528157.7) Description and Page Index

Description: Homo sapiens mesencephalic astrocyte derived neurotrophic factor (MANF), mRNA. (from RefSeq NM_006010)
Gencode Transcript: ENST00000528157.7
Gencode Gene: ENSG00000145050.19
Transcript (Including UTRs)
Position: hg38 chr3:51,385,291-51,389,397 Size: 4,107 Total Exon Count: 4 Strand: +
Coding Region
Position: hg38 chr3:51,385,343-51,389,089 Size: 3,747 Coding Exon Count: 4

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: MANF_HUMAN DESCRIPTION: RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor; AltName: Full=Arginine-rich protein; AltName: Full=Protein ARMET; Flags: Precursor; FUNCTION: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. SUBCELLULAR LOCATION: Secreted. INDUCTION: By endoplasmic reticulum stress. DOMAIN: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. PTM: May contain sialic acid residues. SIMILARITY: Belongs to the ARMET family. CAUTION: Was originally (PubMed:8649854, PubMed:8971156 and PubMed:9174057) thought to be much longer and included an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is now thought to be the 5'-UTR of the mRNA. CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator. SEQUENCE CAUTION: Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019345 - Armet_prot

Pfam Domains:
PF10208 - Degradation arginine-rich protein for mis-folding

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2KVD - NMR

2KVE - NMR

2W51 - X-ray

ModBase Predicted Comparative 3D Structure on P55145


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