Human Gene POU2F2 (ENST00000529067.5) Description and Page Index

Description: Homo sapiens POU class 2 homeobox 2 (POU2F2), transcript variant 4, mRNA. (from RefSeq NM_001247994)
Gencode Transcript: ENST00000529067.5
Gencode Gene: ENSG00000028277.21
Transcript (Including UTRs)
Position: hg38 chr19:42,090,205-42,132,465 Size: 42,261 Total Exon Count: 14 Strand: -
Coding Region
Position: hg38 chr19:42,092,082-42,132,411 Size: 40,330 Coding Exon Count: 13

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: PO2F2_HUMAN DESCRIPTION: RecName: Full=POU domain, class 2, transcription factor 2; AltName: Full=Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; AltName: Full=Octamer-binding protein 2; Short=Oct-2; AltName: Full=Octamer-binding transcription factor 2; Short=OTF-2; FUNCTION: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. SUBUNIT: Interacts with NR3C1, AR and PGR. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147. SIMILARITY: Belongs to the POU transcription factor family. Class- 2 subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 1 POU-specific domain. SEQUENCE CAUTION: Sequence=CAA32039.1; Type=Erroneous initiation;