ID:AGAP1_HUMAN DESCRIPTION: RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; Short=AGAP-1; AltName: Full=Centaurin-gamma-2; Short=Cnt-g2; AltName: Full=GTP-binding and GTPase-activating protein 1; Short=GGAP1; FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. ENZYME REGULATION: GAP activity stimulated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and, to a lesser extent, by phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidic acid potentiates PIP2 stimulation. SUBUNIT: Homodimer. Interacts with several subunits of the AP-3 protein complex: AP3M1, AP3S1 and AP3S2. Interacts with GUCY1A3 and GUCY1B3. SUBCELLULAR LOCATION: Cytoplasm. Note=Associates with the endocytic compartment. TISSUE SPECIFICITY: Widely expressed. DOMAIN: The PH domain mediates AP-3 binding. PTM: Phosphorylated on tyrosines. SIMILARITY: Belongs to the centaurin gamma-like family. SIMILARITY: Contains 2 ANK repeats. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=AAH60814.1; Type=Miscellaneous discrepancy; Note=A 4-nucleotides insertion of unknown origin disrupts the reading frame; Sequence=BAA83051.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91862.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Pfam Domains: PF12796 - Ankyrin repeats (3 copies) PF01412 - Putative GTPase activating protein for Arf PF08477 - Ras of Complex, Roc, domain of DAPkinase PF00169 - PH domain
ModBase Predicted Comparative 3D Structure on Q9UPQ3
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