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Comments and Description Text from UniProtKB
ID:SIAT6_HUMAN DESCRIPTION: RecName: Full=CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; EC=2.4.99.6; AltName: Full=Beta-galactoside alpha-2,3-sialyltransferase 3; Short=Alpha 2,3-ST 3; AltName: Full=Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase; AltName: Full=N-acetyllactosaminide alpha-2,3-sialyltransferase; AltName: Full=ST3Gal III; Short=ST3GalIII; AltName: Full=ST3N; AltName: Full=Sialyltransferase 6; FUNCTION: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc (By similarity). CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-D-galactosyl- (1->4)-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-D- glucosaminyl-glycoprotein. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. TISSUE SPECIFICITY: Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver. PTM: The soluble form derives from the membrane form by proteolytic processing. DISEASE: Defects in ST3GAL3 are the cause of mental retardation autosomal recessive type 12 (MRT12) [MIM:611090]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. SIMILARITY: Belongs to the glycosyltransferase 29 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL3"; WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=ST3Gal III; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_624";
Pfam Domains: PF00777 - Glycosyltransferase family 29 (sialyltransferase)
ModBase Predicted Comparative 3D Structure on Q11203
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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