Human Gene GRPEL2 (ENST00000416916.2) Description and Page Index
Description: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). (from UniProt Q8TAA5) Gencode Transcript: ENST00000416916.2 Gencode Gene: ENSG00000164284.15 Transcript (Including UTRs) Position: hg38 chr5:149,345,502-149,351,654 Size: 6,153 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr5:149,345,540-149,351,055 Size: 5,516 Coding Exon Count: 3
ID:GRPE2_HUMAN DESCRIPTION: RecName: Full=GrpE protein homolog 2, mitochondrial; AltName: Full=Mt-GrpE#2; Flags: Precursor; FUNCTION: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). SUBUNIT: Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19 (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity). SIMILARITY: Belongs to the GrpE family.
ModBase Predicted Comparative 3D Structure on Q8TAA5
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