Human Gene ITGB6 (ENST00000283249.7) Description and Page Index

Description: Homo sapiens integrin subunit beta 6 (ITGB6), transcript variant 6, mRNA. (from RefSeq NM_001282389)
Gencode Transcript: ENST00000283249.7
Gencode Gene: ENSG00000115221.12
Transcript (Including UTRs)
Position: hg38 chr2:160,099,671-160,200,272 Size: 100,602 Total Exon Count: 15 Strand: -
Coding Region
Position: hg38 chr2:160,101,736-160,200,063 Size: 98,328 Coding Exon Count: 15

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: ITB6_HUMAN DESCRIPTION: RecName: Full=Integrin beta-6; Flags: Precursor; FUNCTION: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the integrin beta chain family. SIMILARITY: Contains 1 VWFA domain.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013111 - EGF_extracell
IPR015812 - Integrin_bsu
IPR015436 - Integrin_bsu-6
IPR014836 - Integrin_bsu_cyt
IPR002369 - Integrin_bsu_N
IPR012896 - Integrin_bsu_tail
IPR003659 - Plexin-like
IPR016201 - Plexin-like_fold
IPR002035 - VWF_A

Pfam Domains:
PF07974 - EGF-like domain
PF08725 - Integrin beta cytoplasmic domain
PF07965 - Integrin beta tail domain
PF00362 - Integrin beta chain VWA domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1LH9 - Model

ModBase Predicted Comparative 3D Structure on P18564


Front	Top	Side

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