Human Gene CAPN1 (ENST00000533820.5) Description and Page Index

Description: Homo sapiens calpain 1 (CAPN1), transcript variant 1, mRNA. (from RefSeq NM_001198868)
Gencode Transcript: ENST00000533820.5
Gencode Gene: ENSG00000014216.16
Transcript (Including UTRs)
Position: hg38 chr11:65,181,194-65,212,006 Size: 30,813 Total Exon Count: 22 Strand: +
Coding Region
Position: hg38 chr11:65,182,702-65,211,286 Size: 28,585 Coding Exon Count: 21

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: CAN1_HUMAN DESCRIPTION: RecName: Full=Calpain-1 catalytic subunit; EC=3.4.22.52; AltName: Full=Calcium-activated neutral proteinase 1; Short=CANP 1; AltName: Full=Calpain mu-type; AltName: Full=Calpain-1 large subunit; AltName: Full=Cell proliferation-inducing gene 30 protein; AltName: Full=Micromolar-calpain; Short=muCANP; FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. CATALYTIC ACTIVITY: Broad endopeptidase specificity. COFACTOR: Binds 4 calcium ions. ENZYME REGULATION: Activated by micromolar concentrations of calcium and inhibited by calpastatin. SUBUNIT: Forms a heterodimer with a small (regulatory) subunit (CAPNS1). INTERACTION: P40763:STAT3; NbExp=2; IntAct=EBI-1542113, EBI-518675; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. TISSUE SPECIFICITY: Ubiquitous. PTM: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms. SIMILARITY: Belongs to the peptidase C2 family. SIMILARITY: Contains 1 calpain catalytic domain. SIMILARITY: Contains 4 EF-hand domains. WEB RESOURCE: Name=CaBP; Note=Calpain; URL="http://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html"; WEB RESOURCE: Name=Calpains homepage; URL="http://ag.arizona.edu/calpains/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/capn1/";