ID:MGT5B_HUMAN DESCRIPTION: RecName: Full=Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; EC=2.4.1.-; EC=2.4.1.155; AltName: Full=Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; AltName: Full=GlcNAc-T Vb; Short=GNT-Vb; Short=hGnTVb; AltName: Full=Mannoside acetylglucosaminyltransferase 5B; AltName: Full=N-acetylglucosaminyl-transferase Vb; AltName: Full=N-acetylglucosaminyltransferase IX; Short=GNT-IX; FUNCTION: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl- beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D- mannosyl-R. COFACTOR: Divalent metal cations. According to PubMed:12941944, divalent metal cations do not effect enzyme activity. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). TISSUE SPECIFICITY: Predominantly expressed in brain. Expressed in all area of the adult and fetal brain Also expressed at much lower level in testis, spleen and thymus. SIMILARITY: Belongs to the glycosyltransferase 18 family. SEQUENCE CAUTION: Sequence=AAH62354.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAH63862.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAB71598.1; Type=Miscellaneous discrepancy; Note=Chimeric sequence; Sequence=BAD02406.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE44474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=MGAT5B";
Protein Domain and Structure Information
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