Human Gene RFX4 (ENST00000392842.6) Description and Page Index
  Description: Homo sapiens regulatory factor X4 (RFX4), transcript variant 3, mRNA. (from RefSeq NM_213594)
Gencode Transcript: ENST00000392842.6
Gencode Gene: ENSG00000111783.13
Transcript (Including UTRs)
   Position: hg38 chr12:106,583,004-106,762,803 Size: 179,800 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr12:106,583,321-106,761,469 Size: 178,149 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:106,583,004-106,762,803)mRNA (may differ from genome)Protein (735 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaExonPrimerGeneCards
HGNCMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RFX4_HUMAN
DESCRIPTION: RecName: Full=Transcription factor RFX4; AltName: Full=Regulatory factor X 4; AltName: Full=Testis development protein NYD-SP10;
FUNCTION: May activate transcription by interacting directly with the X-box (By similarity).
SUBUNIT: Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes.
SIMILARITY: Belongs to the RFX family.
SIMILARITY: Contains 1 RFX-type winged-helix DNA-binding domain.
SEQUENCE CAUTION: Sequence=BAB59001.1; Type=Miscellaneous discrepancy; Note=Probable intron retention; Sequence=BAC11288.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48237.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48238.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003150 - DNA-bd_RFX
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF02257 - RFX DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q33E94
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-  Methods, Credits, and Use Restrictions
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