ID:TBB6_HUMAN DESCRIPTION: RecName: Full=Tubulin beta-6 chain; FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity). SUBUNIT: Dimer of alpha and beta chains (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). TISSUE SPECIFICITY: Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all beta-tubulins. Largely decreased expression in most cancerous tissues. DOMAIN: The highly acidic C-terminal region may bind cations such as calcium. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable). SIMILARITY: Belongs to the tubulin family.
ModBase Predicted Comparative 3D Structure on Q9BUF5
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Other Names for This Gene
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