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Comments and Description Text from UniProtKB
ID:FRY_HUMAN DESCRIPTION: RecName: Full=Protein furry homolog; FUNCTION: Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. SUBUNIT: When phosphorylated by CDK1, interacts with PLK1; this interaction occurs in mitotic cells, but not in interphase cells, and leads to further phosphorylation by PLK1. Interacts with AURKA. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. PTM: Phosphorylated by AURKA, CDK1 and PLK1. SIMILARITY: Belongs to the furry protein family. SEQUENCE CAUTION: Sequence=CAB42442.1; Type=Frameshift; Positions=1340, 1378;
ModBase Predicted Comparative 3D Structure on Q5TBA9
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