ID:CD19_HUMAN DESCRIPTION: RecName: Full=B-lymphocyte antigen CD19; AltName: Full=B-lymphocyte surface antigen B4; AltName: Full=Differentiation antigen CD19; AltName: Full=T-cell surface antigen Leu-12; AltName: CD_antigen=CD19; Flags: Precursor; FUNCTION: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B- cell activation. Phosphorylated on tyrosine residues by LYN. DISEASE: Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SEQUENCE CAUTION: Sequence=AAA35533.1; Type=Frameshift; Positions=396; WEB RESOURCE: Name=CD19base; Note=CD19 mutation db; URL="http://bioinf.uta.fi/CD19base/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD19";
ModBase Predicted Comparative 3D Structure on P15391
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