Press "+" in the title bar above to open this section.
Comments and Description Text from UniProtKB
ID:AURKC_HUMAN DESCRIPTION: RecName: Full=Aurora kinase C; EC=2.7.11.1; AltName: Full=Aurora 3; AltName: Full=Aurora/IPL1-related kinase 3; Short=ARK-3; Short=Aurora-related kinase 3; AltName: Full=Aurora/IPL1/Eg2 protein 2; AltName: Full=Serine/threonine-protein kinase 13; AltName: Full=Serine/threonine-protein kinase aurora-C; FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator. SUBUNIT: Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1. SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. INDUCTION: Expression is cell cycle-regulated, with an increase during G2 and M phases. DISEASE: Defects in AURKC are the cause of spermatogenic failure type 5 (SPGF5) [MIM:243060]. An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. SIMILARITY: Contains 1 protein kinase domain.
ModBase Predicted Comparative 3D Structure on Q9UQB9
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Other Names for This Gene
Press "+" in the title bar above to open this section.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.
