Human Gene LIMS1 (ENST00000409441.5) Description and Page Index

Description: Homo sapiens LIM zinc finger domain containing 1 (LIMS1), transcript variant 6, mRNA. (from RefSeq NM_001193484)
Gencode Transcript: ENST00000409441.5
Gencode Gene: ENSG00000169756.16
Transcript (Including UTRs)
Position: hg38 chr2:108,621,266-108,684,448 Size: 63,183 Total Exon Count: 10 Strand: +
Coding Region
Position: hg38 chr2:108,621,355-108,683,999 Size: 62,645 Coding Exon Count: 10

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: LIMS1_HUMAN DESCRIPTION: RecName: Full=LIM and senescent cell antigen-like-containing domain protein 1; AltName: Full=Particularly interesting new Cys-His protein 1; Short=PINCH-1; AltName: Full=Renal carcinoma antigen NY-REN-48; FUNCTION: Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. SUBUNIT: Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts (via LIM zinc-binding 1) with ILK. Interacts with SH3/SH2 adapter NCK2. SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. TISSUE SPECIFICITY: Expressed in most tissues except in the brain. SIMILARITY: Contains 5 LIM zinc-binding domains.