Human Gene PON2 (ENST00000633531.1) Description and Page Index

Description: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. (from UniProt Q15165)
Gencode Transcript: ENST00000633531.1
Gencode Gene: ENSG00000105854.13
Transcript (Including UTRs)
Position: hg38 chr7:95,404,863-95,435,072 Size: 30,210 Total Exon Count: 9 Strand: -
Coding Region
Position: hg38 chr7:95,405,330-95,434,951 Size: 29,622 Coding Exon Count: 9

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: PON2_HUMAN DESCRIPTION: RecName: Full=Serum paraoxonase/arylesterase 2; Short=PON 2; EC=3.1.1.2; EC=3.1.1.81; AltName: Full=Aromatic esterase 2; Short=A-esterase 2; AltName: Full=Serum aryldialkylphosphatase 2; FUNCTION: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. CATALYTIC ACTIVITY: A phenyl acetate + H(2)O = a phenol + acetate. CATALYTIC ACTIVITY: An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. COFACTOR: Binds 2 calcium ions per subunit (By similarity). SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Widely expressed with highest expression in liver, lung, placenta, testis and heart. PTM: The signal sequence is not cleaved (By similarity). SIMILARITY: Belongs to the paraoxonase family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pon2/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PON2";

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR002640 - Arylesterase
IPR008364 - Paraoxonase2

Pfam Domains:
PF01731 - Arylesterase

ModBase Predicted Comparative 3D Structure on Q15165


Front	Top	Side

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