ID:LOX5_HUMAN DESCRIPTION: RecName: Full=Arachidonate 5-lipoxygenase; Short=5-LO; Short=5-lipoxygenase; EC=1.13.11.34; FUNCTION: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. CATALYTIC ACTIVITY: Arachidonate + O(2) = leukotriene A(4) + H(2)O. COFACTOR: Binds 1 iron ion per subunit. COFACTOR: Binds 2 calcium ions per subunit (By similarity). PATHWAY: Lipid metabolism; leukotriene A4 biosynthesis. SUBUNIT: Interacts with ALOX5AP and LTC4S. INTERACTION: Q14019:COTL1; NbExp=4; IntAct=EBI-79934, EBI-79926; SUBCELLULAR LOCATION: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. PTM: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. SIMILARITY: Belongs to the lipoxygenase family. SIMILARITY: Contains 1 lipoxygenase domain. SIMILARITY: Contains 1 PLAT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALOX5ID42985ch10q11.html";
ModBase Predicted Comparative 3D Structure on P09917
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
