Human Gene IL33 (ENST00000417746.6) Description and Page Index

Description: Homo sapiens interleukin 33 (IL33), transcript variant 3, mRNA. (from RefSeq NM_001199641)
Gencode Transcript: ENST00000417746.6
Gencode Gene: ENSG00000137033.11
Transcript (Including UTRs)
Position: hg38 chr9:6,215,786-6,257,982 Size: 42,197 Total Exon Count: 5 Strand: +
Coding Region
Position: hg38 chr9:6,241,695-6,256,168 Size: 14,474 Coding Exon Count: 4

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: IL33_HUMAN DESCRIPTION: RecName: Full=Interleukin-33; Short=IL-33; AltName: Full=Interleukin-1 family member 11; Short=IL-1F11; AltName: Full=Nuclear factor from high endothelial venules; Short=NF-HEV; Flags: Precursor; FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. INTERACTION: Q01638:IL1RL1; NbExp=2; IntAct=EBI-724057, EBI-993762; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. PTM: Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. SIMILARITY: Belongs to the IL-1 family. Highly divergent. CAUTION: Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.