ID:PO2F2_HUMAN DESCRIPTION: RecName: Full=POU domain, class 2, transcription factor 2; AltName: Full=Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; AltName: Full=Octamer-binding protein 2; Short=Oct-2; AltName: Full=Octamer-binding transcription factor 2; Short=OTF-2; FUNCTION: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. SUBUNIT: Interacts with NR3C1, AR and PGR. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus. TISSUE SPECIFICITY: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147. SIMILARITY: Belongs to the POU transcription factor family. Class- 2 subfamily. SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 1 POU-specific domain. SEQUENCE CAUTION: Sequence=CAA32039.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on P09086
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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