Human Gene HYKK (ENST00000563233.2) Description and Page Index

Description: Catalyzes the GTP-dependent phosphorylation of 5- hydroxy-L-lysine. (from UniProt A2RU49)
Gencode Transcript: ENST00000563233.2
Gencode Gene: ENSG00000188266.14
Transcript (Including UTRs)
Position: hg38 chr15:78,513,089-78,537,372 Size: 24,284 Total Exon Count: 4 Strand: +
Coding Region
Position: hg38 chr15:78,513,089-78,537,301 Size: 24,213 Coding Exon Count: 4

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: AGPD1_HUMAN DESCRIPTION: RecName: Full=Hydroxylysine kinase; Short=5-hydroxy-L-lysine kinase; EC=2.7.1.81; AltName: Full=Aminoglycoside phosphotransferase domain-containing protein 1; FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5- hydroxy-L-lysine. CATALYTIC ACTIVITY: GTP + 5-hydroxy-L-lysine = GDP + 5- phosphonooxy-L-lysine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=280 uM for (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP); KM=7.6 uM for (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP); KM=810 uM for ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine); KM=3.5 uM for GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine); Vmax=4.95 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP); Vmax=0.49 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP); Vmax=5.28 umol/min/mg enzyme toward ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine); Vmax=0.57 umol/min/mg enzyme toward GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine); SUBCELLULAR LOCATION: Cytoplasm (Potential). SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.