ID:GLPC_HUMAN DESCRIPTION: RecName: Full=Glycophorin-C; AltName: Full=Glycoconnectin; AltName: Full=Glycophorin-D; Short=GPD; AltName: Full=Glycoprotein beta; AltName: Full=PAS-2'; AltName: Full=Sialoglycoprotein D; AltName: CD_antigen=CD236; FUNCTION: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells. SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1. TISSUE SPECIFICITY: Glycophorin-C is expressed in erythrocytes. Glycophorin-D is ubiquitous. PTM: O-glycosylated with core 1 or possibly core 8 glycans. POLYMORPHISM: GYPC is responsible for the Gerbich blood group system. Deletion of exon 3 in GYPC changes the serologic phenotype of the Gerbich blood group system, resulting in Ge negativity. Ge negative individuals are protected against severe malaria due to erythrocytes resistance to Plasmodium falciparum invasion [MIM:611162]. SIMILARITY: Belongs to the glycophorin-C family. SEQUENCE CAUTION: Sequence=CAA32093.1; Type=Frameshift; Positions=35; WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=gerbich"; WEB RESOURCE: Name=Wikipedia; Note=Glycophorin C entry; URL="http://en.wikipedia.org/wiki/Glycophorin_C"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gypc/";
ModBase Predicted Comparative 3D Structure on P04921
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